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Article

Unraveling the therapeutic potential of the Hedgehog pathway in cancer.

Nature medicine - 1 Nov 2013

Amakye Dereck, Jagani Zainab, Dorsch Marion

Abstract excerpt

Major progress has been made in recent years in the development of Hedgehog (Hh) pathway inhibitors for the treatment of patients with cancer. Promising clinical trial results have been obtained in cancers that harbor activating mutations of the Hh pathway, such as basal cell carcinoma and medulloblastoma. However, for many cancers, in which Hh ligand overexpression is thought to drive tumor growth, results have...

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PMID: 24202394
DOI: 10.1038/nm.3389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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