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Design of Hedgehog pathway inhibitors for cancer treatment

28 Nov 2018

Abstract excerpt

Hedgehog (Hh) signaling is involved in the initiation and progression of various cancers and is essential for embryonic and postnatal development. This pathway remains in the quiescent state in adult tissues but gets activated upon inflammation and injuries. Inhibition of Hh signaling pathway using natural and synthetic compounds has provided an attractive approach for treating cancer and inflammatory diseases....

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PMID: 30484872
DOI: 10.1002/med.21555

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