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Article

Increasing adipocyte lipoprotein lipase improves glucose metabolism in high fat diet-induced obesity.

The Journal of biological chemistry - 1 May 2015

Walton R Grace, Zhu Beibei, Unal Resat, Spencer Michael, Sunkara Manjula, Morris Andrew J, Charnigo Richard, Katz Wendy S, Daugherty Alan, Howatt Deborah A, Kern Philip A, Finlin Brian S

Abstract excerpt

Lipid accumulation in liver and skeletal muscle contributes to co-morbidities associated with diabetes and obesity. We made a transgenic mouse in which the adiponectin (Adipoq) promoter drives expression of lipoprotein lipase (LPL) in adipocytes to potentially increase adipose tissue lipid storage. These mice (Adipoq-LPL) have improved glucose and insulin tolerance as well as increased energy expenditure when...

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Topics

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Share to Adipocytes
Share to Diet, High-Fat

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucose

Share to Insulin Resistance

Share to Lipoprotein Lipase

Share to Mice, Transgenic

Share to Obesity

Share to Thiazolidinediones

Source

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Identifiers

PMID: 25784555
DOI: 10.1074/jbc.M114.628487
PMCID: PMC4416858

Genes

LPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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