Article
Lipoprotein lipase expression exclusively in liver. A mouse model for metabolism in the neonatal period and during cachexia.
The Journal of clinical investigation - 1 Sept 1998
Merkel M, Weinstock P H, Chajek-Shaul T, Radner H, Yin B, Breslow J L, Goldberg I J
Abstract excerpt
Lipoprotein lipase (LPL), the rate-limiting enzyme in triglyceride hydrolysis, is normally not expressed in the liver of adult humans and animals. However, liver LPL is found in the perinatal period, and in adults it can be induced by cytokines. To study the metabolic consequences of liver LPL expression, transgenic mice producing human LPL specifically in the liver were generated and crossed onto the LPL...
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