Article

ANGPTL4 from adipose, but not liver, is responsible for regulating plasma triglyceride partitioning

2020-06-03

Abstract excerpt

<h4>ABSTRACT</h4> Elevated plasma triglyceride levels are associated with metabolic disease. Angiopoietin-like protein 4 (ANGPTL4) regulates plasma triglyceride levels by inhibiting lipoprotein lipase (LPL). Our aim was to investigate the role of tissue-specific ANGPTL4 expression in the setting of high fat diet. Adipocyte- and hepatocyte-specific ANGPTL4 deficient mice were fed a high fat diet (60% kCal from fat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6db3c582-7c31-5ca8-b61e-be0326739cef
DOI: 10.1101/2020.06.02.106815

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ANGPTL4 from adipose, but not liver, is responsible for regulating plasma triglyceride partitioningDOI 10.1101/2020.06.02.106815Read

Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis.Semantic proximity Read

The C-terminal fibrinogen-like domain of angiopoietin-like 4 stimulates adipose tissue lipolysis and promotes energy expenditure.Semantic proximity Read

Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice.Semantic proximity Read

Atypical angiopoietin-like protein that regulates ANGPTL3Semantic proximity Read

Angiopoietin-like 3 in lipoprotein metabolism.Semantic proximity Read

Adipose Factor ANGPTL4: Its Role in Aging Mechanisms and Associated DiseasesSemantic proximity Read

Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans.Semantic proximity Read

Fasting induces ANGPTL4 and reduces LPL activity in human adipose tissueSemantic proximity Read

Targeting Circulating FABP4 Ameliorates Obesity-Associated Hepatic SteatosisSemantic proximity Read

Adipose-specific lipoprotein lipase deficiency more profoundly affects brown than white fat biology.Semantic proximity Read

Angptl3 regulates lipid metabolism in mice.Semantic proximity Read

ANGPTL8: An Important Regulator in Metabolic DisordersSemantic proximity Read