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Article

VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses.

PloS one - 1 Jan 2011

Brown Jonathan D, Oligino Eric, Rader Daniel J, Saghatelian Alan, Plutzky Jorge

Abstract excerpt

BACKGROUND: PPARs (α,γ,δ) are a family of ligand-activated transcription factors that regulate energy balance, including lipid metabolism. Despite these critical functions, the integration between specific pathways of lipid metabolism and distinct PPAR responses remains obscure. Previous work has revealed that lipolytic pathways can activate PPARs. Whether hepatic lipase (HL), an enzyme that regulates VLDL and...

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Identifiers

PMID: 21750705
DOI: 10.1371/journal.pone.0021209
PMCID: PMC3130023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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