Article
Adipose-specific lipoprotein lipase deficiency more profoundly affects brown than white fat biology.
The Journal of biological chemistry - 17 May 2013
Garcia-Arcos Itsaso, Hiyama Yaeko, Drosatos Konstantinos, Bharadwaj Kalyani G, Hu Yunying, Son Ni Huiping, O'Byrne Sheila M, Chang Chuchun L, Deckelbaum Richard J, Takahashi Manabu, Westerterp Marit, Obunike Joseph C, Jiang Hongfeng, Yagyu Hiroaki, Blaner William S, Goldberg Ira J
Abstract excerpt
Adipose fat storage is thought to require uptake of circulating triglyceride (TG)-derived fatty acids via lipoprotein lipase (LpL). To determine how LpL affects the biology of adipose tissue, we created adipose-specific LpL knock-out (ATLO) mice, and we compared them with whole body LpL knock-out mice rescued with muscle LpL expression (MCK/L0) and wild type (WT) mice. ATLO LpL mRNA and activity were reduced,...
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