Adipocyte ATP-binding cassette G1 promotes triglyceride storage, fat mass growth, and human obesity.

doi:10.2337/db14-0245

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Article

Adipocyte ATP-binding cassette G1 promotes triglyceride storage, fat mass growth, and human obesity.

Diabetes - 1 Mar 2015

Frisdal Eric, Le Lay Soazig, Hooton Henri, Poupel Lucie, Olivier Maryline, Alili Rohia, Plengpanich Wanee, Villard Elise F, Gilibert Sophie, Lhomme Marie, Superville Alexandre, Miftah-Alkhair Lobna, Chapman M John, Dallinga-Thie Geesje M, Venteclef Nicolas, Poitou Christine, Tordjman Joan, Lesnik Philippe, Kontush Anatol, Huby Thierry, Dugail Isabelle, Clement Karine, Guerin Maryse, Le Goff Wilfried

Abstract excerpt

The role of the ATP-binding cassette G1 (ABCG1) transporter in human pathophysiology is still largely unknown. Indeed, beyond its role in mediating free cholesterol efflux to HDL, the ABCG1 transporter equally promotes lipid accumulation in a triglyceride (TG)-rich environment through regulation of the bioavailability of lipoprotein lipase (LPL). Because both ABCG1 and LPL are expressed in adipose tissue, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25249572
DOI: 10.2337/db14-0245

Genes

ABCG1
LPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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