Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Obesity-associated improvements in metabolic profile through expansion of adipose tissue.

The Journal of clinical investigation - 1 Sept 2007

Kim Ja-Young, van de Wall Esther, Laplante Mathieu, Azzara Anthony, Trujillo Maria E, Hofmann Susanna M, Schraw Todd, Durand Jorge L, Li Hua, Li Guangyu, Jelicks Linda A, Mehler Mark F, Hui David Y, Deshaies Yves, Shulman Gerald I, Schwartz Gary J, Scherer Philipp E

Abstract excerpt

Excess caloric intake can lead to insulin resistance. The underlying reasons are complex but likely related to ectopic lipid deposition in nonadipose tissue. We hypothesized that the inability to appropriately expand subcutaneous adipose tissue may be an underlying reason for insulin resistance and beta cell failure. Mice lacking leptin while overexpressing adiponectin showed normalized glucose and insulin levels...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adiponectin
Share to Animal Feed

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diglycerides

Share to Islets of Langerhans

Share to Leptin

Share to Lipoproteins

Share to PPAR gamma

Source

Open in PubMed Open full text

Identifiers

PMID: 17717599
DOI: 10.1172/JCI31021
PMCID: PMC1950456

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Obesity-associated improvements in metabolic profile through expansion of adipose tissue.PMID 17717599Read ↗

The inflammation highway: metabolism accelerates inflammatory traffic in obesitySemantic proximity Read ↗

Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice.Semantic proximity Read ↗

High-Fat Diet-Induced Obesity Promotes Expansion of Bone Marrow Adipose Tissue and Impairs Skeletal Stem Cell Functions in Mice.Semantic proximity Read ↗

Brown adipose expansion and remission of glycemic dysfunction in obese SM/J miceSemantic proximity Read ↗

Leptin Deficiency Unmasks the Deleterious Effects of Impaired Peroxisome Proliferator–Activated Receptor γ Function (P465L PPARγ) in MiceSemantic proximity Read ↗

Pathophysiology of human visceral obesity: an update.Semantic proximity Read ↗

The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function.Semantic proximity Read ↗

Novel hyperplastic expansion of white adipose tissue underlies the metabolically healthy obese phenotype of male LFABP null miceSemantic proximity Read ↗

Update on adipocyte hormones: regulation of energy balance and carbohydrate/lipid metabolism.Semantic proximity Read ↗

Metabolic effects of leptin receptor knockdown or reconstitution in adipose tissuesSemantic proximity Read ↗

Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome.Semantic proximity Read ↗

Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissueSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.