Article
The human cytomegalovirus protein UL147A downregulates the most prevalent MICA allele: MICA*008, to evade NK cell-mediated killing.
PLoS pathogens - 1 May 2021
Seidel Einat, Dassa Liat, Schuler Corinna, Oiknine-Djian Esther, Wolf Dana G, Le-Trilling Vu Thuy Khanh, Mandelboim Ofer
Abstract excerpt
Natural killer (NK) cells are innate immune lymphocytes capable of killing target cells without prior sensitization. One pivotal activating NK receptor is NKG2D, which binds a family of eight ligands, including the major histocompatibility complex (MHC) class I-related chain A (MICA). Human cytomegalovirus (HCMV) is a ubiquitous betaherpesvirus causing morbidity and mortality in immunosuppressed patients and...
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