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Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection

30 Mar 2009

Abstract excerpt

The activating natural killer (NK) cell receptor Ly49H recognizes the mouse cytomegalovirus (MCMV) m157 glycoprotein expressed on the surface of infected cells and is required for protection against MCMV. Although Ly49H has previously been shown to signal via DAP12, we now show that Ly49H must also associate with and signal via DAP10 for optimal function. In the absence of DAP12, DAP10 enables Ly49H-mediated...

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PMID: 19332875
DOI: 10.1084/jem.20090168

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