A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects.

doi:10.1038/sj.gene.6364414

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects.

Genes and immunity - 1 Oct 2007

Rafiq S, Frayling T M, Murray A, Hurst A, Stevens K, Weedon M N, Henley W, Ferrucci L, Bandinelli S, Corsi A-M, Guralnik J M, Melzer D

Abstract excerpt

Interleukin-6 (IL-6) is a key inflammatory cytokine, signalling to most tissues by binding to a soluble IL-6 receptor (sIL-6r), making a complex with gp130. We used 1273 subjects (mean age 68 years) from the InCHIANTI Italian cohort to study common variation in the IL-6r locus and associations with interleukin 6 receptor (IL-6r), IL-6, gp130 and a battery of inflammatory markers. The rs4537545 single nucleotide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alleles

Share to Cytokine Receptor gp130

Share to Cytokines

Share to Inflammation

Share to Interleukin-6

Share to Polymorphism, Single Nucleotide

Share to Receptors, Interleukin-6

Source

Open in PubMed Open full text

Identifiers

PMID: 17671508
DOI: 10.1038/sj.gene.6364414
PMCID: PMC2668154

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects.PMID 17671508Read ↗

Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases.Semantic proximity Read ↗

Leveraging genetic data to investigate the effects of interleukin-6 receptor signalling on levels of 40 circulating cytokines.Semantic proximity Read ↗

Genome-wide association study of circulating interleukin 6 levels identifies novel loci.Semantic proximity Read ↗

Cumulative Evidence for Associations Between Genetic Variants in Interleukin 6 Receptor Gene and Human Diseases and Phenotypes.Semantic proximity Read ↗

Leveraging genetic data to investigate the effects of interleukin‐6 receptor signalling on levels of 40 circulating cytokinesSemantic proximity Read ↗

Interleukin-6: it’s role in the organism, genetic polymorphism and significance in certain diseases (literature review)Semantic proximity Read ↗

Interleukin-6 receptor gene variations, plasma interleukin-6 levels, and type 2 diabetes in U.S. Women.Semantic proximity Read ↗

The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases.Semantic proximity Read ↗

Interleukin-6 receptor gene polymorphism modulates interleukin-6 levels and the metabolic syndrome: GBCS-CVD.Semantic proximity Read ↗

Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers.Semantic proximity Read ↗

Differential Associations of Interleukin 6 Receptor Variant Across Genetic Ancestries and Implications for Targeted TherapiesSemantic proximity Read ↗

Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.