Article
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies.
Lancet (London, England) - 31 Mar 2012
Sarwar Nadeem, Butterworth Adam S, Freitag Daniel F, Gregson John, Willeit Peter, Gorman Donal N, Gao Pei, Saleheen Danish, Rendon Augusto, Nelson Christopher P, Braund Peter S, Hall Alistair S, Chasman Daniel I, Tybjærg-Hansen Anne, Chambers John C, Benjamin Emelia J, Franks Paul W, Clarke Robert, Wilde Arthur A M, Trip Mieke D, Steri Maristella, Witteman Jacqueline C M, Qi Lu, van der Schoot C Ellen, de Faire Ulf, Erdmann Jeanette, Stringham Heather M, Koenig Wolfgang, Rader Daniel J, Melzer David, Reich David, Psaty Bruce M, Kleber Marcus E, Panagiotakos Demosthenes B, Willeit Johann, Wennberg Patrik, Woodward Mark, Adamovic Svetlana, Rimm Eric B, Meade Tom W, Gillum Richard F, Shaffer Jonathan A, Hofman Albert, Onat Altan, Sundström Johan, Wassertheil-Smoller Sylvia, Mellström Dan, Gallacher John, Cushman Mary, Tracy Russell P, Kauhanen Jussi, Karlsson Magnus, Salonen Jukka T, Wilhelmsen Lars, Amouyel Philippe, Cantin Bernard, Best Lyle G, Ben-Shlomo Yoav, Manson JoAnn E, Davey-Smith George, de Bakker Paul I W, O'Donnell Christopher J, Wilson James F, Wilson Anthony G, Assimes Themistocles L, Jansson John-Olov, Ohlsson Claes, Tivesten Åsa, Ljunggren Östen, Reilly Muredach P, Hamsten Anders, Ingelsson Erik, Cambien Francois, Hung Joseph, Thomas G Neil, Boehnke Michael, Schunkert Heribert, Asselbergs Folkert W, Kastelein John J P, Gudnason Vilmundur, Salomaa Veikko, Harris Tamara B, Kooner Jaspal S, Allin Kristine H, Nordestgaard Børge G, Hopewell Jemma C, Goodall Alison H, Ridker Paul M, Hólm Hilma, Watkins Hugh, Ouwehand Willem H, Samani Nilesh J, Kaptoge Stephen, Di Angelantonio Emanuele, Harari Olivier, Danesh John
Abstract excerpt
BACKGROUND: Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling. METHODS: In a collaborative meta-analysis, we...
