Article
Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers.
Circulation. Cardiovascular genetics - 1 Apr 2013
Shah Tina, Zabaneh Delilah, Gaunt Tom, Swerdlow Daniel I, Shah Sonia, Talmud Philippa J, Day Ian N, Whittaker John, Holmes Michael V, Sofat Reecha, Humphries Steve E, Kivimaki Mika, Kumari Meena, Hingorani Aroon D, Casas Juan P
Abstract excerpt
BACKGROUND- Inflammatory cytokine interleukin-6 (IL-6), a possible risk factor for coronary heart disease, has an estimated heritability of >60%, but to date few genetic variants influencing IL-6 levels are known. METHODS AND RESULTS- We used the ITMAT-Broad-Care (IBC) HumanCVD disease BeadChip in the Whitehall II study (N=4911) and British Women's Heart and Health Study (N=3445) to identify single-nucleotide...
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