Article
CD4+ T cell-derived IL-21 and deprivation of CD40 signaling favor the in vivo development of granzyme B-expressing regulatory B cells in HIV patients.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2015
Kaltenmeier Christof, Gawanbacht Ali, Beyer Thamara, Lindner Stefanie, Trzaska Timo, van der Merwe Johannes Andreas, Härter Georg, Grüner Beate, Fabricius Dorit, Lotfi Ramin, Schwarz Klaus, Schütz Catharina, Hönig Manfred, Schulz Ansgar, Kern Peter, Bommer Martin, Schrezenmeier Hubert, Kirchhoff Frank, Jahrsdörfer Bernd
Abstract excerpt
IL-21 can induce both plasma cells and regulatory B cells. In this article, we demonstrate that untreated HIV patients display CD4(+) T cells with enhanced IL-21 expression and high in vivo frequencies of regulatory B cells overexpressing the serine protease granzyme B. Granzyme B-expressing regulatory B cells (GraB cells) cells from HIV patients exhibit increased expression of CD5, CD43, CD86, and CD147 but do...
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