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Article

Trafficking phenotype and production of granzyme B by double negative B cells (IgG(+)IgD(-)CD27(-)) in the elderly.

Experimental gerontology - 1 Jun 2014

Bulati Matteo, Buffa Silvio, Martorana Adriana, Candore Giuseppina, Lio Domenico, Caruso Calogero, Colonna-Romano Giuseppina

Abstract excerpt

The impairment of humoral immune response in elderly humans has been extensively demonstrated. We have reported the increase of memory B cells (IgG(+)IgD(-)CD27(-), double negative, DN) population in the elderly, in which there is also a typical inflammatory micro-environment. In order to evaluate whether this pro-inflammatory status could influence the trafficking phenotype of naïve/memory B cells, we have...

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PMID: 24389059
DOI: 10.1016/j.exger.2013.12.011

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BCR
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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