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Article

HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcome.

Science translational medicine - 29 Feb 2012

Soghoian Damien Z, Jessen Heiko, Flanders Michael, Sierra-Davidson Kailan, Cutler Sam, Pertel Thomas, Ranasinghe Srinika, Lindqvist Madelene, Davis Isaiah, Lane Kimberly, Rychert Jenna, Rosenberg Eric S, Piechocka-Trocha Alicja, Brass Abraham L, Brenchley Jason M, Walker Bruce D, Streeck Hendrik

Abstract excerpt

Early immunological events during acute HIV infection are thought to fundamentally influence long-term disease outcome. Whereas the contribution of HIV-specific CD8 T cell responses to early viral control is well established, the role of HIV-specific CD4 T cell responses in the control of viral replication after acute infection is unknown. A growing body of evidence suggests that CD4 T cells-besides their helper...

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Identifiers

PMID: 22378925
DOI: 10.1126/scitranslmed.3003165
PMCID: PMC3918726

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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