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Article

Primary HIV-1 infection sets the stage for important B lymphocyte dysfunctions.

AIDS (London, England) - 18 Nov 2005

Titanji Kehmia, Chiodi Francesca, Bellocco Rino, Schepis Danika, Osorio Lyda, Tassandin Chiara, Tambussi Giuseppe, Grutzmeier Sven, Lopalco Lucia, De Milito Angelo

Abstract excerpt

OBJECTIVES: To investigate the effects of primary HIV-1 infection (PHI) and of two antiretroviral therapies [highly active antiretroviral therapy (HAART) or reverse transcriptase inhibitors (RTI)] on activation, differentiation and survival of B cells. METHODS: Naive and memory B cells from three groups [PHI (31), chronic infection (26) and healthy donors (12)] were studied for surface expression of Fas, LAIR-1,...

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Identifiers

PMID: 16260900
DOI: 10.1097/01.aids.0000191231.54170.89

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