Article
Interleukin 21-induced granzyme B-expressing B cells infiltrate tumors and regulate T cells.
Cancer research - 15 Apr 2013
Lindner Stefanie, Dahlke Karen, Sontheimer Kai, Hagn Magdalena, Kaltenmeier Christof, Barth Thomas F E, Beyer Thamara, Reister Frank, Fabricius Dorit, Lotfi Ramin, Lunov Oleg, Nienhaus G Ulrich, Simmet Thomas, Kreienberg Rolf, Möller Peter, Schrezenmeier Hubert, Jahrsdörfer Bernd
Abstract excerpt
The pathogenic impact of tumor-infiltrating B cells is unresolved at present, however, some studies suggest that they may have immune regulatory potential. Here, we report that the microenvironment of various solid tumors includes B cells that express granzyme B (GrB, GZMB), where these B cells can be found adjacent to interleukin (IL)-21-secreting regulatory T cells (Treg) that contribute to immune tolerance of...
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