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Article

Decoupling activation and exhaustion of B cells in spontaneous controllers of HIV infection

8 Nov 2012

Abstract excerpt

OBJECTIVE: To define the impact of chronic viremia and associated immune activation on B-cell exhaustion in HIV infection. DESIGN: Progressive HIV infection is marked by B-cell anergy and exhaustion coupled with dramatic hypergammaglobulinemia. Although both upregulation of CD95 and loss of CD21 have been used as markers of infection-associated B-cell dysfunction, little is known regarding the specific profiles...

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PMID: 23135171
DOI: 10.1097/qad.0b013e32835bd1f0

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