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Dissociated Production of Perforin, Granzyme B, and IFN-γ by HIV-Specific CD8 <sup>+</sup> Cells in HIV Infection

1 Jan 2008

Abstract excerpt

CD8(+) T cells play a crucial role in the control of viral infections such as HIV. The functional characterization of HIV-specific CD8(+) T cells has so far been largely restricted to studies of IFN-gamma. The TCR-triggered release of the effector molecules perforin (PFN) and granzyme B (GzB), however, is thought to be a central pathway for the destruction of virus-infected target cells by CD8(+) effector T...

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Identifiers

PMID: 18275349
DOI: 10.1089/aid.2007.0125

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