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Article

Comparison of next-generation sequencing and mutation-specific platforms in clinical practice.

American journal of clinical pathology - 1 Apr 2015

Hinrichs John W J, van Blokland W T Marja, Moons Michiel J, Radersma Remco D, Radersma-van Loon Joyce H, de Voijs Carmen M A, Rappel Sophie B, Koudijs Marco J, Besselink Nicolle J M, Willems Stefan M, de Weger Roel A

Abstract excerpt

OBJECTIVES: To compare next-generation sequencing (NGS) platforms with mutation-specific analysis platforms in a clinical setting, in terms of sensitivity, mutation specificity, costs, capacity, and ease of use. METHODS: We analyzed 25 formalin-fixed, paraffin-embedded lung cancer samples of different size and tumor percentage for known KRAS and EGFR hotspot mutations with two dedicated genotyping platforms...

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Identifiers

PMID: 25780010
DOI: 10.1309/AJCP40XETVYAMJPY

Genes

KRAS
EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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