Prospective Clinical Integration of an Amplicon-Based Next-Generation Sequencing Method to Select Advanced Non-Small-Cell Lung Cancer Patients for Genotype-Tailored Treatments.

doi:10.1016/j.cllc.2017.06.008

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Article

Prospective Clinical Integration of an Amplicon-Based Next-Generation Sequencing Method to Select Advanced Non-Small-Cell Lung Cancer Patients for Genotype-Tailored Treatments.

Clinical lung cancer - 1 Jan 2018

Zugazagoitia Jon, Rueda Daniel, Carrizo Nuria, Enguita Ana Belen, Gómez-Sánchez David, Díaz-Serrano Asunción, Jiménez Elisabeth, Mérida Antonio, Calero Rosa, Lujan Ricardo, De Miguel Eduardo, Gámez Pablo, Díaz-Hellín Vicente, Nuñez Juan Antonio, Iglesias Lara, Ferrer Irene, Paz-Ares Luis, Ponce-Aix Santiago

Abstract excerpt

INTRODUCTION: A substantial fraction of non-small-cell lung cancers (NSCLCs) harbor targetable genetic alterations. In this study, we analyzed the feasibility and clinical utility of integrating a next-generation sequencing (NGS) panel into our routine lung cancer molecular subtyping algorithm. PATIENTS AND METHODS: After routine pathologic and molecular subtyping, we implemented an amplicon-based gene panel for...

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PMID: 28780976
DOI: 10.1016/j.cllc.2017.06.008

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