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Article

Validation of next generation sequencing technologies in comparison to current diagnostic gold standards for BRAF, EGFR and KRAS mutational analysis.

PloS one - 1 Jan 2013

McCourt Clare M, McArt Darragh G, Mills Ken, Catherwood Mark A, Maxwell Perry, Waugh David J, Hamilton Peter, O'Sullivan Joe M, Salto-Tellez Manuel

Abstract excerpt

Next Generation Sequencing (NGS) has the potential of becoming an important tool in clinical diagnosis and therapeutic decision-making in oncology owing to its enhanced sensitivity in DNA mutation detection, fast-turnaround of samples in comparison to current gold standard methods and the potential to sequence a large number of cancer-driving genes at the one time. We aim to test the diagnostic accuracy of...

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Identifiers

PMID: 23922754
DOI: 10.1371/journal.pone.0069604
PMCID: PMC3724913

Genes

BRAF
EGFR
KRAS

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