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Article

Clinical Genotyping of Non-Small Cell Lung Cancers Using Targeted Next-Generation Sequencing: Utility of Identifying Rare and Co-mutations in Oncogenic Driver Genes.

Neoplasia (New York, N.Y.) - 1 Sept 2016

Tafe Laura J, Pierce Kirsten J, Peterson Jason D, de Abreu Francine, Memoli Vincent A, Black Candice C, Pettus Jason R, Marotti Jonathan D, Gutmann Edward J, Liu Xiaoying, Shirai Keisuke, Dragnev Konstantin H, Amos Christopher I, Tsongalis Gregory J

Abstract excerpt

Detection of somatic mutations in non-small cell lung cancers (NSCLCs), especially adenocarcinomas, is important for directing patient care when targeted therapy is available. Here, we present our experience with genotyping NSCLC using the Ion Torrent Personal Genome Machine (PGM) and the AmpliSeq Cancer Hotspot Panel v2. We tested 453 NSCLC samples from 407 individual patients using the 50 gene AmpliSeq Cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

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Source

Open in PubMed Open full text

Identifiers

PMID: 27659017
DOI: 10.1016/j.neo.2016.07.010
PMCID: PMC5031899

Genes

BRAF
EGFR
KRAS
ERBB2
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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