Article

Yeast as a platform to dissect <i>Magnaporthe oryaze</i> poly(ADP-ribose) polymerase function and evaluate PARP inhibitors

2025-12-30

Abstract excerpt

Poly(ADP-ribose) polymerases (PARPs) regulate genome maintenance through NAD + -dependent ADP-ribosylation, yet PARP function in fungi remains poorly defined. Here, we reconstituted the activity of the Magnaporthe oryzae PARP1 homolog (MoPARP1) in Saccharomyces cerevisiae , a genetically tractable organism that lacks endogenous PARP enzymes. Galactose-induced expression of MoPARP1 reduced yeast growth, whereas...

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Literature Corpus work: de61de0c-3dfa-5eeb-bbeb-348b580ab52d
DOI: 10.64898/2025.12.29.696956

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