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Knockout of Poly(ADP-ribose) polymerase 1 in human cell line: Influence on the Base Excision Repair Reactions in the Cellular Extracts

2023-12-12

Abstract excerpt

Base excision repair (BER) is the predominant pathway to remove most forms of hydrolytic, oxidative and alkylative DNA damage. The precise functioning of BER is achieving by the regulation of each step by regulatory/accessory proteins, with the most important of which being poly(ADP-ribose) polymerase 1 (PARP1). The PARP1 regulatory functions extend to many cellular processes including regulation of mRNA stability...

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Identifiers and source

Literature Corpus work
0193f422-6417-5ee0-a8e7-ba4a0b1a535f
DOI
10.20944/preprints202312.0830.v1
Open publication

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