Article
A novel Alzheimer disease locus located near the gene encoding tau protein.
Molecular psychiatry - 1 Jan 2016
Jun G, Ibrahim-Verbaas C A, Vronskaya M, Lambert J-C, Chung J, Naj A C, Kunkle B W, Wang L-S, Bis J C, Bellenguez C, Harold D, Lunetta K L, Destefano A L, Grenier-Boley B, Sims R, Beecham G W, Smith A V, Chouraki V, Hamilton-Nelson K L, Ikram M A, Fievet N, Denning N, Martin E R, Schmidt H, Kamatani Y, Dunstan M L, Valladares O, Laza A R, Zelenika D, Ramirez A, Foroud T M, Choi S-H, Boland A, Becker T, Kukull W A, van der Lee S J, Pasquier F, Cruchaga C, Beekly D, Fitzpatrick A L, Hanon O, Gill M, Barber R, Gudnason V, Campion D, Love S, Bennett D A, Amin N, Berr C, Tsolaki Magda, Buxbaum J D, Lopez O L, Deramecourt V, Fox N C, Cantwell L B, Tárraga L, Dufouil C, Hardy J, Crane P K, Eiriksdottir G, Hannequin D, Clarke R, Evans D, Mosley T H, Letenneur L, Brayne C, Maier W, De Jager P, Emilsson V, Dartigues J-F, Hampel H, Kamboh M I, de Bruijn R F A G, Tzourio C, Pastor P, Larson E B, Rotter J I, O'Donovan M C, Montine T J, Nalls M A, Mead S, Reiman E M, Jonsson P V, Holmes C, St George-Hyslop P H, Boada M, Passmore P, Wendland J R, Schmidt R, Morgan K, Winslow A R, Powell J F, Carasquillo M, Younkin S G, Jakobsdóttir J, Kauwe J S K, Wilhelmsen K C, Rujescu D, Nöthen M M, Hofman A, Jones L, Haines J L, Psaty B M, Van Broeckhoven C, Holmans P, Launer L J, Mayeux R, Lathrop M, Goate A M, Escott-Price V, Seshadri S, Pericak-Vance M A, Amouyel P, Williams J, van Duijn C M, Schellenberg G D, Farrer L A
Abstract excerpt
APOE ɛ4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer's Project (IGAP) Consortium in APOE ɛ4+ (10 352 cases and 9207 controls) and APOE ɛ4- (7184 cases and 26 968 controls) subgroups as well as in the total sample testing for interaction between a...
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