Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LMTK2 and CRB1 are two novel risk genes for Alzheimer's disease in Han Chinese

7 Feb 2025

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is the most prevalent neurodegenerative disease with a substantial genetic background. However, its underlying genetic architecture remains to be elucidated. METHODS: In this study, we performed whole-exome sequencing in 282 familial and/or early-onset AD patients and 1086 cognitively normal controls in the Han Chinse populations. According to minor allele frequency, variants...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Genetic Associations and Epidemiology
Share to Genomics and Rare Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39922756
DOI: 10.1016/j.tjpad.2025.100087

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LMTK2 and CRB1 are two novel risk genes for Alzheimer's disease in Han ChinesePMID 39922756Read ↗

Integrating rare pathogenic variant prioritization with gene-based association analysis to identify novel genes and relevant multimodal traits for Alzheimer's disease.Semantic proximity Read ↗

Ethnic-specific effects of the LILRB2-LILRB5 locus and newly identified risk loci for Alzheimer's disease in the East Asian population.Semantic proximity Read ↗

Genome-Wide Meta-Analysis of Late-Onset Alzheimer’s Disease Using Rare Variant Imputation in 65,602 Subjects Identifies Novel Rare Variant Locus <i>NCK2</i>: The International Genomics of Alzheimer’s Project (IGAP)Semantic proximity Read ↗

Challenge accepted: uncovering the role of rare genetic variants in Alzheimer's disease.Semantic proximity Read ↗

Explore the role of CR1 genetic variants in late-onset Alzheimer's disease susceptibility.Semantic proximity Read ↗

A rare variant in MLKL confers susceptibility to ApoE ɛ4-negative Alzheimer's disease in Hong Kong Chinese population.Semantic proximity Read ↗

Whole-genome sequencing study in Koreans identifies novel loci for Alzheimer's disease.Semantic proximity Read ↗

Alzheimer's diseases in America, Europe, and Asian regions: a global genetic variation.Semantic proximity Read ↗

Whole-genome sequencing reveals novel ethnicity-specific rare variants associated with Alzheimer's disease.Semantic proximity Read ↗

CLU rs9331888 Polymorphism Contributes to Alzheimer's Disease Susceptibility in Caucasian But Not East Asian Populations.Semantic proximity Read ↗

Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population.Semantic proximity Read ↗

Association of rare variants in neurodegenerative genes with familial Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.