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Article

Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study.

Journal of Alzheimer's disease : JAD - 1 Jan 2010

Laumet Geoffroy, Chouraki Vincent, Grenier-Boley Benjamin, Legry Vanessa, Heath Simon, Zelenika Diana, Fievet Nathalie, Hannequin Didier, Delepine Marc, Pasquier Florence, Hanon Olivier, Brice Alexis, Epelbaum Jacques, Berr Claudine, Dartigues Jean-Francois, Tzourio Christophe, Campion Dominique, Lathrop Mark, Bertram Lars, Amouyel Philippe, Lambert Jean-Charles

Abstract excerpt

We selected twenty genes from the "Top Results" list on the AlzGene database website and assessed their association with risk of developing Alzheimer's disease (AD) in a large, genome-wide association study (using 526 SNPs from 2,032 AD cases and 5,328 controls) performed in France. The APOE, CLU, PICALM, and CR1 loci were excluded, since they had already been extensively analyzed. Ten genes/loci (TFAM, SORL1,...

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Source

Identifiers

PMID: 20413850
DOI: 10.3233/JAD-2010-100126

Genes

CHRNB2
TFAM
ACE
APOE
BDNF
CLU
CST3
DAPK1
GAB2
MTHFR
NEDD9
PICALM
PRNP
SORCS1
SORL1
TNK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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