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Article

Conserved role of Sonic Hedgehog in tonotopic organization of the avian basilar papilla and mammalian cochlea.

Proceedings of the National Academy of Sciences of the United States of America - 24 Mar 2015

Son Eun Jin, Ma Ji-Hyun, Ankamreddy Harinarayana, Shin Jeong-Oh, Choi Jae Young, Wu Doris K, Bok Jinwoong

Abstract excerpt

Sound frequency discrimination begins at the organ of Corti in mammals and the basilar papilla in birds. Both of these hearing organs are tonotopically organized such that sensory hair cells at the basal (proximal) end respond to high frequency sound, whereas their counterparts at the apex (distal) respond to low frequencies. Sonic hedgehog (Shh) secreted by the developing notochord and floor plate is required...

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Source

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Identifiers

PMID: 25775517
DOI: 10.1073/pnas.1417856112
PMCID: PMC4378437

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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