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Article

The Notch ligand Jagged1 is required for inner ear sensory development.

Proceedings of the National Academy of Sciences of the United States of America - 27 Mar 2001

Kiernan A E, Ahituv N, Fuchs H, Balling R, Avraham K B, Steel K P, Hrabé de Angelis M

Abstract excerpt

Within the mammalian inner ear there are six separate sensory regions that subserve the functions of hearing and balance, although how these sensory regions become specified remains unknown. Each sensory region is populated by two cell types, the mechanosensory hair cell and the supporting cell, which are arranged in a mosaic in which each hair cell is surrounded by supporting cells. The proposed mechanism for...

Topics

Amino Acid Sequence
Animals
Calcium-Binding Proteins
Chromosome Mapping
Chromosomes
Ear, Inner
Homozygote
Humans
Intercellular Signaling Peptides and Proteins
Jagged-1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Mice

Mice, Inbred C3H

Mice, Inbred C57BL

Molecular Sequence Data

Mutation, Missense

Phenotype

Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 11259677
DOI: 10.1073/pnas.071496998
PMCID: PMC31145

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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The Notch ligand Jagged1 is required for inner ear sensory development.PMID 11259677Read ↗

The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear.Semantic proximity Read ↗

Jag1 represses Notch activation in lateral supporting cells and inhibits an outer hair cell fate in the medial compartment of the developing cochleaSemantic proximity Read ↗

Notch signalling pathway mediates hair cell development in mammalian cochlea.Semantic proximity Read ↗

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Notch signaling during cell fate determination in the inner ear.Semantic proximity Read ↗

Lmx1a is required for segregation of sensory epithelia and normal ear histogenesis and morphogenesis.Semantic proximity Read ↗

Foxg1 is required for morphogenesis and histogenesis of the mammalian inner ear.Semantic proximity Read ↗

Rbpj regulates development of prosensory cells in the mammalian inner ear.Semantic proximity Read ↗

The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear.Semantic proximity Read ↗

Requirement for Jagged1-Notch2 signaling in patterning the bones of the mouse and human middle earSemantic proximity Read ↗

Hedgehog Signaling Regulates Sensory Cell Formation and Auditory Function in Mice and HumansSemantic proximity Read ↗

Neurod1 suppresses hair cell differentiation in ear ganglia and regulates hair cell subtype development in the cochlea.Semantic proximity Read ↗

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