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Article

Notch signalling pathway mediates hair cell development in mammalian cochlea.

Nature genetics - 1 Mar 1999

Lanford P J, Lan Y, Jiang R, Lindsell C, Weinmaster G, Gridley T, Kelley M W

Abstract excerpt

The mammalian cochlea contains an invariant mosaic of sensory hair cells and non-sensory supporting cells reminiscent of invertebrate structures such as the compound eye in Drosophila melanogaster. The sensory epithelium in the mammalian cochlea (the organ of Corti) contains four rows of mechanosensory hair cells: a single row of inner hair cells and three rows of outer hair cells. Each hair cell is separated...

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Source

Identifiers

PMID: 10080181
DOI: 10.1038/6804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Notch signalling pathway mediates hair cell development in mammalian cochlea.PMID 10080181Read ↗

The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear.Semantic proximity Read ↗

The Notch ligand Jagged1 is required for inner ear sensory development.Semantic proximity Read ↗

The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear.Semantic proximity Read ↗

Jag1 represses Notch activation in lateral supporting cells and inhibits an outer hair cell fate in the medial compartment of the developing cochleaSemantic proximity Read ↗

Expression of Math1 and HES5 in the cochleae of wildtype and Jag2 mutant mice.Semantic proximity Read ↗

Notch signaling during cell fate determination in the inner ear.Semantic proximity Read ↗

Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells.Semantic proximity Read ↗

Neurod1 suppresses hair cell differentiation in ear ganglia and regulates hair cell subtype development in the cochlea.Semantic proximity Read ↗

Notch/Notch ligands and Math1 expression patterns in the organ of Corti of wild-type and Hes1 and Hes5 mutant mice.Semantic proximity Read ↗

Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates.Semantic proximity Read ↗

β-Catenin is required for hair-cell differentiation in the cochlea.Semantic proximity Read ↗

Notch signaling limits supporting cell plasticity in the hair cell-damaged early postnatal murine cochlea.Semantic proximity Read ↗

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