Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hox2 Genes Are Required for Tonotopic Map Precision and Sound Discrimination in the Mouse Auditory Brainstem.

Cell reports - 3 Jan 2017

Karmakar Kajari, Narita Yuichi, Fadok Jonathan, Ducret Sebastien, Loche Alberto, Kitazawa Taro, Genoud Christel, Di Meglio Thomas, Thierry Raphael, Bacelo Joao, Lüthi Andreas, Rijli Filippo M

Abstract excerpt

Tonotopy is a hallmark of auditory pathways and provides the basis for sound discrimination. Little is known about the involvement of transcription factors in brainstem cochlear neurons orchestrating the tonotopic precision of pre-synaptic input. We found that in the absence of Hoxa2 and Hoxb2 function in Atoh1-derived glutamatergic bushy cells of the anterior ventral cochlear nucleus, broad input topography and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Audiometry, Pure-Tone
Share to Auditory Perception

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brain Stem

Share to Conditioning, Psychological

Share to Glutamates

Share to Organogenesis

Share to Synaptic Transmission

Source

Identifiers

PMID: 28052248
DOI: 10.1016/j.celrep.2016.12.021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hox2 Genes Are Required for Tonotopic Map Precision and Sound Discrimination in the Mouse Auditory Brainstem.PMID 28052248Read ↗

Ephrin-A3 is required for tonotopic map precision and auditory functions in the mouse auditory brainstem.Semantic proximity Read ↗

Null mutations in EphB receptors decrease sharpness of frequency tuning in primary auditory cortex.Semantic proximity Read ↗

Mutation of Npr2 leads to blurred tonotopic organization of central auditory circuits in mice.Semantic proximity Read ↗

Graded and discontinuous EphA-ephrinB expression patterns in the developing auditory brainstem.Semantic proximity Read ↗

Hair Cell Mechanotransduction Regulates Spontaneous Activity and Spiral Ganglion Subtype Specification in the Auditory System.Semantic proximity Read ↗

Conserved role of Sonic Hedgehog in tonotopic organization of the avian basilar papilla and mammalian cochlea.Semantic proximity Read ↗

Maintenance of neuronal size gradient in MNTB requires sound-evoked activity.Semantic proximity Read ↗

Gating of hair cell Ca <sup>2+</sup> channels governs the activity of cochlear neuronsSemantic proximity Read ↗

An Etiological Foxp2 Mutation Impairs Neuronal Gain in Layer VI Cortico-Thalamic Cells through Increased GABAB/GIRK Signaling.Semantic proximity Read ↗

Complex primary afferents: What the distribution of electrophysiologically-relevant phenotypes within the spiral ganglion tells us about peripheral neural coding.Semantic proximity Read ↗

Reduced influence of the ipsilateral ear on spatial tuning of auditory neurons in the albino superior colliculus: a knock-on effect of anomalies of the acoustic chiasm?Semantic proximity Read ↗

Concurrent maturation of inner hair cell synaptic Ca2+ influx and auditory nerve spontaneous activity around hearing onset in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.