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Article

The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear.

PLoS genetics - 1 Jan 2006

Kiernan Amy E, Xu Jingxia, Gridley Thomas

Abstract excerpt

In mammals, six separate sensory regions in the inner ear are essential for hearing and balance function. Each sensory region is made up of hair cells, which are the sensory cells, and their associated supporting cells, both arising from a common progenitor. Little is known about the molecular mechanisms that govern the development of these sensory organs. Notch signaling plays a pivotal role in the...

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Share to Calcium-Binding Proteins
Share to Cyclin-Dependent Kinase Inhibitor p27
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Intercellular Signaling Peptides and Proteins

Share to Jagged-1 Protein

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Source

Open in PubMed Open full text

Identifiers

PMID: 16410827
DOI: 10.1371/journal.pgen.0020004
PMCID: PMC1326221

Genes

JAG1
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear.PMID 16410827Read ↗

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The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear.Semantic proximity Read ↗

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