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Article

Ephrin-A3 is required for tonotopic map precision and auditory functions in the mouse auditory brainstem.

The Journal of comparative neurology - 1 Nov 2021

Hoshino Natalia, Altarshan Yazan, Alzein Ahmad, Fernando Amali M, Nguyen Hieu T, Majewski Emma F, Chen Vincent C-F, Rochlin M William, Yu Wei-Ming

Abstract excerpt

Tonotopy is a prominent feature of the vertebrate auditory system and forms the basis for sound discrimination, but the molecular mechanism that underlies its formation remains largely elusive. Ephrin/Eph signaling is known to play important roles in axon guidance during topographic mapping in other sensory systems, so we investigated its possible role in the establishment of tonotopy in the mouse cochlear...

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Identifiers

PMID: 34235739
DOI: 10.1002/cne.25213
PMCID: PMC8490280

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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