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Article

A Push-Pull Mechanism Between PRRT2 and β4-subunit Differentially Regulates Membrane Exposure and Biophysical Properties of NaV1.2 Sodium Channels.

Molecular neurobiology - 1 Mar 2023

Valente Pierluigi, Marte Antonella, Franchi Francesca, Sterlini Bruno, Casagrande Silvia, Corradi Anna, Baldelli Pietro, Benfenati Fabio

Abstract excerpt

Proline-rich transmembrane protein 2 (PRRT2) is a neuron-specific protein implicated in the control of neurotransmitter release and neural network stability. Accordingly, PRRT2 loss-of-function mutations associate with pleiotropic paroxysmal neurological disorders, including paroxysmal kinesigenic dyskinesia, episodic ataxia, benign familial infantile seizures, and hemiplegic migraine. PRRT2 is a negative...

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PMID: 36441479
DOI: 10.1007/s12035-022-03112-x
PMCID: PMC9899197

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