Article
Robustness-epistasis link shapes the fitness landscape of a randomly drifting protein.
Nature - 14 Dec 2006
Bershtein Shimon, Segal Michal, Bekerman Roy, Tokuriki Nobuhiko, Tawfik Dan S
Abstract excerpt
The distribution of fitness effects of protein mutations is still unknown. Of particular interest is whether accumulating deleterious mutations interact, and how the resulting epistatic effects shape the protein's fitness landscape. Here we apply a model system in which bacterial fitness correlates with the enzymatic activity of TEM-1 beta-lactamase (antibiotic degradation). Subjecting TEM-1 to random mutational...
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