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Article

Adaptive protein evolution grants organismal fitness by improving catalysis and flexibility.

Proceedings of the National Academy of Sciences of the United States of America - 30 Dec 2008

Tomatis Pablo E, Fabiane Stella M, Simona Fabio, Carloni Paolo, Sutton Brian J, Vila Alejandro J

Abstract excerpt

Protein evolution is crucial for organismal adaptation and fitness. This process takes place by shaping a given 3-dimensional fold for its particular biochemical function within the metabolic requirements and constraints of the environment. The complex interplay between sequence, structure, funct...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19098096
DOI: 10.1073/pnas.0807989106
PMCID: PMC2634896

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19098096-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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