Article
A mutasynthesis approach with a Penicillium chrysogenum ΔroqA strain yields new roquefortine D analogues.
Chembiochem : a European journal of chemical biology - 13 Apr 2015
Ouchaou Kahina, Maire Florian, Salo Oleksandr, Ali Hazrat, Hankemeier Thomas, van der Marel Gijsbert A, Filippov Dmitri V, Bovenberg Roel A L, Vreeken Rob J, Driessen Arnold J M, Overkleeft Herman S
Abstract excerpt
Penicillium chrysogenum, which lacks the roqA gene, processes synthetic, exogenously added histidyltryptophanyldiketopiperazine (HTD) to yield a set of roquefortine-based secondary metabolites also produced by the wild-type strain. Feeding a number of synthetic HTD analogues to the ΔroqA strain gives rise to the biosynthesis of a number of new roquefortine D derivatives, depending on the nature of the synthetic...
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