Article
Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum.
Proceedings of the National Academy of Sciences of the United States of America - 3 Mar 2015
McLean Kirsty J, Hans Marcus, Meijrink Ben, van Scheppingen Wibo B, Vollebregt Aad, Tee Kang Lan, van der Laan Jan-Metske, Leys David, Munro Andrew W, van den Berg Marco A
Abstract excerpt
The cholesterol-lowering blockbuster drug pravastatin can be produced by stereoselective hydroxylation of the natural product compactin. We report here the metabolic reprogramming of the antibiotics producer Penicillium chrysogenum toward an industrial pravastatin production process. Following the successful introduction of the compactin pathway into the β-lactam-negative P. chrysogenum DS50662, a new cytochrome...
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