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Functional Reconstitution of a Fungal Natural Product Gene Cluster by Advanced Genome Editing

9 Sept 2016

Abstract excerpt

Filamentous fungi produce varieties of natural products even in a strain dependent manner. However, the genetic basis of chemical speciation between strains is still widely unknown. One example is trypacidin, a natural product of the opportunistic human pathogen Aspergillus fumigatus, which is not produced among different isolates. Combining computational analysis with targeted gene editing, we could link a...

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PMID: 27611015
DOI: 10.1021/acssynbio.6b00203

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