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Article

Reengineering a tryptophan halogenase to preferentially chlorinate a direct alkaloid precursor.

Journal of the American Chemical Society - 7 Dec 2011

Glenn Weslee S, Nims Ezekiel, O'Connor Sarah E

Abstract excerpt

Installing halogens onto natural products can generate compounds with novel or improved properties. Notably, enzymatic halogenation is now possible as a result of the discovery of several classes of halogenases; however, applications are limited because of the narrow substrate specificity of these enzymes. Here we demonstrate that the flavin-dependent halogenase RebH can be engineered to install chlorine...

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PMID: 22050348
DOI: 10.1021/ja2089348

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