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Article

Engineering unnatural variants of plantazolicin through codon reprogramming.

ACS chemical biology - 20 Sept 2013

Deane Caitlin D, Melby Joel O, Molohon Katie J, Susarrey Aziz R, Mitchell Douglas A

Abstract excerpt

Plantazolicin (PZN) is a polyheterocyclic natural product derived from a ribosomal peptide that harbors remarkable antibiotic selectivity for the causative agent of anthrax, Bacillus anthracis. To simultaneously establish the structure-activity relationship of PZN and the substrate tolerance of the biosynthetic pathway, an Escherichia coli expression strain was engineered to heterologously produce PZN analogues....

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PMID: 23823732
DOI: 10.1021/cb4003392
PMCID: PMC3783559

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