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Piperazine ring formation by a single-module NRPS and cleavage by an α-KG-dependent nonheme iron dioxygenase in brasiliamide biosynthesis.

Applied microbiology and biotechnology - 1 Jul 2020

Yuan Bochuan, Liu Dong, Guan Xin, Yan Yunchen, Zhang Jianping, Zhang Yiping, Yang Donghui, Ma Ming, Lin Wenhan

Abstract excerpt

Brasiliamides are a class of piperazine-containing alkaloids produced by Penicillium brasilianum with a range of pharmaceutical activities. The mechanism of brasiliamide biosynthesis, including piperazine ring formation and multiple tailoring modifications, still remains unclear. In this study, the biosynthetic gene cluster of brasiliamides, brs, was identified from the marine-derived fungal strain Penicillium...

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PMID: 32436033
DOI: 10.1007/s00253-020-10678-w

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