Article
Genomic mutational analysis of the impact of the classical strain improvement program on β-lactam producing Penicillium chrysogenum.
BMC genomics - 14 Nov 2015
Salo Oleksandr V, Ries Marco, Medema Marnix H, Lankhorst Peter P, Vreeken Rob J, Bovenberg Roel A L, Driessen Arnold J M
Abstract excerpt
BACKGROUND: Penicillium chrysogenum is a filamentous fungus that is employed as an industrial producer of β-lactams. The high β-lactam titers of current strains is the result of a classical strain improvement program (CSI) starting with a wild-type like strain more than six decades ago. This involved extensive mutagenesis and strain selection for improved β-lactam titers and growth characteristics. However, the...
Topics
- Genes, Fungal
- Metabolome
- Multigene Family
- Mutation
- Penicillium chrysogenum
- Species Specificity
- beta-Lactams