Article
Impact of Classical Strain Improvement of Penicillium rubens on Amino Acid Metabolism during β-Lactam Production.
Applied and environmental microbiology - 21 Jan 2020
Wu Min, Crismaru Ciprian G, Salo Oleksandr, Bovenberg Roel A L, Driessen Arnold J M
Abstract excerpt
To produce high levels of β-lactams, the filamentous fungus Penicillium rubens (previously named Penicillium chrysogenum) has been subjected to an extensive classical strain improvement (CSI) program during the last few decades. This has led to the accumulation of many mutations that were spread over the genome. Detailed analysis reveals that several mutations targeted genes that encode enzymes involved in amino...
Topics
- Amino Acids
- Biosynthetic Pathways
- Cysteine
- Escherichia coli
- Microorganisms, Genetically-Modified
- Mutation
- Penicillins
- Penicillium chrysogenum
- beta-Lactams