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Article

Limited topological alteration of the T7 RNA polymerase active center at intrinsic termination sites.

Biochemistry - 5 Mar 2002

Boudvillain Marc, Schwartz Annie, Rahmouni A Rachid

Abstract excerpt

Transcription terminators trigger the dissociation of RNA polymerase elongation complexes and the release of RNA products at specific DNA template positions. The mechanism by which these signals alter the catalytic properties of the highly processive elongation transcription complexes is unclear. Here, we propose that intrinsic terminators impede transcript elongation by promoting a misarrangement of reactants...

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PMID: 11863453
DOI: 10.1021/bi011358q

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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