Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional compromises among pH tolerance, site specificity, and sequence tolerance for a DNA-hydrolyzing deoxyribozyme.

Biochemistry - 9 Nov 2010

Xiao Ying, Chandra Madhavaiah, Silverman Scott K

Abstract excerpt

We recently reported the identification by in vitro selection of 10MD5, a deoxyribozyme that requires both Mn2+ and Zn2+ to hydrolyze a single-stranded DNA substrate with formation of 5′-phosphate and 3′-hydroxyl termini. DNA cleavage by 10MD5 proceeds with kobs=2.7 h(−1) and rate enhancement of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cloning, Molecular
Share to DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Catalytic

Share to Hydrogen-Ion Concentration

Share to Hydrolysis

Share to Mutation

Share to Phylogeny

Source

Open in PubMed Open full text

Identifiers

PMID: 20923239
DOI: 10.1021/bi1013672
PMCID: PMC3030634

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20923239-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional compromises among pH tolerance, site specificity, and sequence tolerance for a DNA-hydrolyzing deoxyribozyme.PMID 20923239Read ↗

Characterization of a catalytically efficient acidic RNA-cleaving deoxyribozyme.Semantic proximity Read ↗

Optimization and generality of a small deoxyribozyme that ligates RNA.Semantic proximity Read ↗

Large Scale Mutational and Kinetic Analysis of a Self-Hydrolyzing Deoxyribozyme.Semantic proximity Read ↗

Characterizing the secondary structure and identifying functionally essential nucleotides of pH6DZ1, a fluorescence-signaling and RNA-cleaving deoxyribozyme.Semantic proximity Read ↗

Zn2+-dependent DNAzymes that cleave all combinations of ribonucleotides.Semantic proximity Read ↗

Chemical evolution of an autonomous DNAzyme with allele-specific gene silencing activity.Semantic proximity Read ↗

A new and efficient DNA enzyme for the sequence-specific cleavage of RNA.Semantic proximity Read ↗

Characterization of long RNA-cleaving deoxyribozymes with short catalytic cores: the effect of excess sequence elements on the outcome of in vitro selection.Semantic proximity Read ↗

Coordination of divalent metal ions in the active site of poly(A)-specific ribonuclease.Semantic proximity Read ↗

Mechanistic Studies Reveal Similar Catalytic Strategies for Phosphodiester Bond Hydrolysis by Protein-only and RNA-dependent Ribonuclease P.Semantic proximity Read ↗

Sequence-function relationships provide new insight into the cleavage site selectivity of the 8-17 RNA-cleaving deoxyribozyme.Semantic proximity Read ↗

Generic expansion of the substrate spectrum of a DNA polymerase by directed evolution.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.