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Article

A Type IA DNA/RNA Topoisomerase with RNA Hydrolysis Activity Participates in Ribosomal RNA Processing.

Journal of molecular biology - 18 Sept 2020

Rani Phoolwanti, Kalladi Shashwath Malli, Bansia Harsh, Rao Sandhya, Jha Rajiv Kumar, Jain Paras, Bhaduri Tisha, Nagaraja Valakunja

Abstract excerpt

Topoisomerases maintain topological homeostasis of bacterial chromosomes by catalysing changes in DNA linking number. The resolution of RNA entanglements occurring in the cell would also require catalytic action of topoisomerases. We describe RNA topoisomerase and hydrolysis activities in DNA topoisomerase I (topo I) from mycobacteria. The interaction of topo I with mRNA, tRNA and rRNA suggested its role in some...

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PMID: 32818489
DOI: 10.1016/j.jmb.2020.08.012

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